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Output under NMITLI projects
| S.No. | Project Title | Technology Developed | Knowledge base | No. of Patent and /or Publications |
|---|---|---|---|---|
| 1. | Two orders of magnitude improved liquid crystals for flat panel display devices | • The knowledge gained couldnot be translated for industrial purpose as the expertise for developing graphic display system was unavailable at that time. | • Knowledge on development of display system with improved characteristics; • New LCD materials were synthesized, characterized and developed; and • A prototype of 16 characters, single-line alphanumeric device developed. | Patents: 6, Publications: 2. |
| 2 | Defunctionalization of carbohydrates as a feed stock to manufacture well identified industrial chemicals | · The process could not be commercialized as it was beyond the scope of NMITLI and for other process the change in market dynamics made the process not viable. | • Developed a process for 5-hydroxy methyl furfural. But - requires huge effort to commercialize -beyond scope of NMITLI; • Developed a novel process for (S)3-hydroxy-g- butyrolactone. | One international and one Indian patent obtained. |
| 3 | New targets and markers for cancer using genomics and proteomics | --- | · Several differentially expressed genes and protein biomarkers identified from oral cancer tissues that can be exploited for diagnostic purposes. | • Patent filed on these markers. |
| 4 | Stimuli sensitive polymeric nano-particle based advanced drug delivery systems for cancer, diabetes and anti-bacterials | Technical hurdles faced while developing virosome and nanoparticle based drug delivery systems for anti-cancer and anti-bacterial drugs—Project component closed | · POC established for inhalation delivery of anti TB drugs | Three patent filed. |
| 5 | 5 & 25 KW decentralized power packs | The technology however could not become commercially viable. | · A prototype of integrated 5 kW Fuel Cell was developed, installed and demonstrated. | Patent filed: 4 Publications: 4 |
| 6 | Latent M. Tuberculosis: New Targets, Drug Delivery system, bio-enhancers and therapeutics | --- | · A new bioenhancer as an adjunct to chemotherapy established for latent tuberculosis infection; · 4 promising leads identified as candidates for IND | -- |
| 7 | Using Functional genomics in tea, mentha, ashwagandha, plants for gene expression modulation | · Agrotechnologies for New plant varieties of Mentha Pipereta ‘CIM-Indus’ & ‘CIM-Madhuras’ released to farmers; · A kit for catechin estmation | · Bidirectional and two element dependent novel gene expression vectors; · Tea database profling for catechins; · Agrobacterium mediated genetic transformation system. | Publications:42 Patents:Filed – 3, Granted – 6 |
| 8 | Meso-scale modeling for monsoon predictions II | · Developed and demonstrated integrated weather prediction platform consisting of 128 nodes parallel processor supercomputer with Floswitch and Flo-opti link for inter-processor communication; · Integrated Platform for monsoon prediction developed under CSIR-NMITLI & MoES | · A new weather prediction code Varsha 1.0 with physics relevant to the tropics ported on computer; · The platform was further upgraded by developing and demonstrating a 10 Teraflop Supercomputing Hardware Machine (Mk8) and improved software code (Varsha 1.1) with a higher resolution of 40 / 20 Km. The hardware machine consisted of many indigenously developed components, like new FPGA based FloSwitch etc. | --- |
| 9 | Nano-material catalysts and associated process technology for alkylation/ acylation/nitration of well identified industrial chemicals, pre-reforming of hydro-carbons and sulphur removal (<50 ppm) from petroleum fuels | · Technology could not be developed for commercial scale | · Process for removal of sulphur from petroleum fuels demonstrated; · Catalysts developed for pre-reforming of hydrocarbons | Patents: 3 |
| 10 | Versatile, portable PC based software for bioinformatics & Development of Linux cluster version of Bio-suite | Two bioinformatics softwares developed and marketed (i) BioSuite, both cluster version and stand alone; and (ii) Genocluster | -- | • Patents: Filed -2 • Publications: 10 |
| 11 | Biodegradable plastics from agricultural wastes: Cellulose esters based on bagasse & Steam explosion-based fractionation process of sugarcane bagasse to cellulose, hemicellulose and lignin-Validation at semi-commercial level | A world class technology for fractionation of sugarcane bagasse into cellulose, hemi-cellulose and lignin developed and licensed to M/s Godavari Biorefineries Ltd. | -- | US Patent granted |
| 12 | Herbal based preparations for degenerative disorders: Diabetes mellitus type II, Osteoarthritis and Rheumatoid arthritis and Common hepatic disorders | -- | Diabetes · Single herbal formulation developed and validated through limited multi-centric clinical studies in patients uncontrolled on existing drugs: sulphonylurea and metformin. Arthritis · Polyherbal formulation comprising 3 herbs developed and validated through large-scale multi-centric clinical studies. Hepatocellular Protection · Polyherbal formulation comprising 12 herbs developed and validated through limited multi-centric clinical studies. | · Publications: 25 on Arthritis component · Arthritis Patent granted in Europe--Great Britain and Denmark |
| 13 | Biotechnology for replacing chemical process in leather Sector-Phase-I & II | · Technology for Bio-processing of Leather (beam house operations). · A total of 5 proteases and 2 lipases have been developed and up-scaled for dehairing, degreasing and fibre opening along with alpha-amylase (other source). · Technology demonstrated by CLRI in tanneries. | -- | 1 Patent granted. |
| 14 | Enhanced productivity in cement manufacture through improved granular processing and resource conservation | -- | · Developed computational fluid dynamics based model of rotary cement kiln; · Demonstrated utilization of slag and flyash in preparation of Portland Slag Cement | 18 Publications; 4 Indian patents; 1 US patent; 1 Canada patent |
| 15 | Development of an Oral herbal formulation for treatment of Psoriasis a clinical and scientific challenge & Clinical studies of an oral herbal formulation for treatment of psoriasis & Phase-IIb & III Clinical Trials | -- | · Formulation developed for amelioration of Psoriasis; · However it failed to show efficacy in Phase III clinical trial in comparison to standard drug, methotrexate. | -- |
| 16 | Development of novel biotech therapeutic molecule –Lysostaphin & Phase-II Clinical studies: Novel bio-therapeutic molecule-Lysostaphin & Novel Biotherapeutic Molecule: Lysostaphin – Phase IIb/III Clinical studies | -- | · Developed lysostaphin gel formulation for Staphylococcus aureus infection; · Developed novel downstream process for large scale production of >99% pure protein; · However Phase III clinical trial couldnot show improved efficacy as compared to standard treatment available. | The IP on the molecule is protected through PCT with product patent in 85 countries, including USA. |
| 17 | Microbiological conversion of Erythromycin to Clarithromycin and other novel biologically active molecules | --- | · Project attempted to isolate microorganism that can convert biological active molecules to antimicrobials but failed in its attempt. | --- |
| 18 | Environmentally secure rare earth based colorants for surface coatings & Phase II | --- | · Forty-two color shades based on rare earth compounds and selected dopants were developed for use in pigment applications for surface coatings; · Innovative combustion synthesis based route for cerium sulphides and oxysulfides and lanthanum sulphide to develop new range of colors; · Sulfate reducing bacteria based method developed that showed promise in securing environment. | 1 US patent granted |
| 19 | Functionalization of alkanes | --- | · A modified catalytic process for economical production of acetic acid and ethylene from ethane was developed; · A modified catalytic process for production of vinyl chloride monomer from ethane was developed. | 2 patents granted |
| 20 | Novel molecular diagnostics for eye diseases and low vision enhancement devices & Development of DNA Macroarray for the detection of eye infections and the genetic predisposition to glaucoma | · Three low vision enhancement devices developed viz. a) The Illumination Table with Variable Spectral Distribution and Intensity b) Night Vision Pocketscope and c) Spectacle mounted prismatic stereovision lenses of plastic with anti-scratch coating. · Diagnostic system for detection of eye infection commercialized. | · A macrochip containing 4 candidate gene to facilitate easy and rapid diagnosis and clinical characterization of individual eye has been developed. | --- |
| 21 | Nano-material coatings and advanced composites for tribological applications in automotive industry | --- | · ROTOPLASMA XPT 512 coated cast iron sleeve cylinder blocks for reduced oil consumption, reduced wear rate and retention of surface finish compared to regular cast iron cylinder liners were developed; · Aluminium alloy matrix hybrid composite containing silicon and graphite particles were developed, synthesized and characterized; · A process for making functionally graded aluminium matrix composite cylinder liners was developed. | 12 Publications 1 Indian patent granted. |
| 22 | Value added polymeric materials from renewable resources: Lactic acid and lactic acid based polymers & Lactic acid and lactic acid based polymers-establishment of 300 TPA pilot plant for lactic acid production | · Process for production of lactic acid (3000 litre capacity) from fermented sugarcane juice by lactobacillus and its separation as calcium lactide was demonstrated at industry site, M/s Godavari sugar mills Ltd; · Technology however could not be made commercially viable due to market conditions. | · A mutant strain of lactobacillus delbrueckii MAC 168701 isolated that can produce L-lactic acid; · A lab scale (100 l) fermentation process demonstrated for production of highly pure lactic acid from sugarcane juice; | ---- |
| 23 | Recombinant approach to produce a-linolenic acid and docosahexanoic acid (DHA) in sunflower and yeast | § A technology for the production of DHA from fermentation of thraustochytrids species SC-1 has been developed and transferred to industry partner for commercial exploitation. | · Recombinant approach for production of DHA was attempted but was not successful. | ---- |
| 24 | A cost effective Simple Office Computing (Sofcomp) platform to replace PC | · Three variants of SofComp devices developed. | -- | Copyrights: 3 |
| 25 | A PC based high-end 3D visualization platform for computational biology – ‘Darshee’ | · A low cost visualization platform for bioinformatics with features of portability, scalability and upgradability developed. · Product marketed as part of Industry’s Avadis platform; · The technology was further integrated into Array Assist of Stratagene, USA. | --- | --- |
| 26 | Improved Genome Annotation Through a Combination of Machine Learning and Experimental Methods: Plasmodium falciparum As a Case Study | ---- | · Algorithms and softwares developed for predicting, identification and annotation of genes in prokaryotes using P. falciparum as case study; · The genes predicted using the softwares developed have been experimentally verified using gene expression studies | --- |
| 27 | Oral Delivery of Insulin | --- | · Development of oral insulin formulation was attempted but was not successful. | 1 patent has been granted. |
| 28 | Pharmacological and Genomic Investigations on Withania somnifera - An Indian Medicinal Plant & Leads based drug development and genetic improvement of Ashwagandha (Withania somnifera) | · Five chemotypes namely, NMITLI 101, NMITLI 108, NMITLI 118, NMITLI 128 and NMITLI 135 and a phytochemical hybrid (NMITLI 101XNMITLI 135) were developed; · NMITLI 118 variety released to farmers. · Agrotechnologies for NMITLI Ashwagandha varieties developed; · NMITLI 101 variety released to farmers. | · Indian chemotype varieties developed and fingerprinted; · Pharmacological activities of different varieties deduced; · Marker compounds from Ashwagandha root extracts developed as phytochemical standards; · Ashwagandha monograph publishe · Antistroke activity proved using NMITLI 118 extract in animal models; · NMITLI 101 extract proved to be best immunomodulator clearing more than 90% Leishmania and Candida infections in animal models. | 1 US patent granted. More than 20 publications 3 patents filed; 43 publications |
| 29 | Development of Novel Fungicides | --- | · Novel fungicides synthesized which have strobilurin and 1,2,4 triazoles unit in them showed activity against pathogenic fungi at 25 ppm.; · Suitable formulations developed and they were subjected to field trial by industry; · Targets for few compounds were identified for their mechanism of action; · Antifungal compounds were isolated from microbes (Psuedomonas sp) growing in extremophilic and mesophilic environment; · Industry partner deployed these fungicides in their field as a part of trial. | 1 Indian patent granted and a PCT application published in few countries |
| 30 | Biotechnological Approaches for Improvement of Plant Species with Special Reference to Pulp and Paper | --- | · Project efforts led to rich collection of Ochlandra germplasm being maintained at KFRI, Peechi which has low lignin content suitable for paper industry; · Eight elites of Leucaena lecocephala (subabul) havng high fibre length and low lignin content are being maintained at NBRI; · Micropropagation techniques and regeneration system for mass multiplication developed for these varieties which are useful for paper industries. | ---- |
| 31 | Development of fuel cells based on Hydrogen & Development and demonstration of polymer electrolyte fuel cell stacks for stationary applications & Demonstration and Validation of 3kWe PEMFC System | A prototype of 1.00 kW based on the Polymer Electrolyte Membrane Fuel Cell (PEFC) technology has been designed, developed and demonstrated. | · Knowhow for modified membrane for the operation of PEMFC at low relative humidity and high temperature;· A modular 3kWe PEFMC test bed designed, built and commissioned at RIL’s Patalganga site where adequate amount of hydrogen is available. | --- |
| 32 | Development of a 500 kW low cost horizontal-axis Wind Turbine | 500 kW horizontal-axis wind turbine has been designed, fabricated and successfully commissioned at the test site, Kethanur, Tamil Nadu | ---- | --- |
| 33 | Novel expression system | ---- | · Five novel promoters were developed that drive the production of some industrially important enzymes; · Five novel yeast species were identified from varied sources; · Alcohol oxidase promoter were developed from novel alcohol oxidase genes cloned from a yeast strain. | One Indian patent |
| 34 | Development of selected Medical Implants And Development of Dental Implants-Phase II study | Dental implants of sizes based on anthropometric measurement for Indian patients and complete surgical accessories developed; Technology transferred to M/s IHPL; Dental implants commercialized in the nameof ifix by KMPL, Faridabad. | · Prototype for titanium nitride coated drug eluting cardiovascular stents were designed and prototypes fabricated; · Ceramic based femoral head, acetabular cup and ceramic hip prosthesis developed and trial was done in pvt clinical centers; · Hydoxyapatite and bioglass coating of orthopaedic implants developed. | One US patent and One Indian patent on dental implants obtained. |
| 35 | Genetic Improvement of Jatropha curcas for Adaptability and Oil Yield | · 185 accessions of Jatropha collected from wild were systematically characterized and genotypically mapped; · Germplasm bank established at NBRI and NBPGR Ranchi; · Agrotechnology for plant establishment in place through multilocational trial; · Genetic transformation methods developed using stress related gene from plant. | · Patents filed: 2 · Publications: 36 | |
| 36 | Development of Globally competitive ‘Triple-Play’ Broadband Technology | The triple play technology has been successfully developed and tested using the BSNL broadband infrastructure to provide end-to-end solution for triple play services. BSNL was fully satisfied with the technology and adopted it for commercialization. | --- | An Indian patent (No. 201179) granted. |
| 37 | Novel formulation for treatment of pulmonary tuberculosis – clinical studies | --- | The formulation from the molecule did not showed desired protection in TB patients as compared to protection seen in animal model. | Patents: 3 |
| 38 | Market seeding of SofComp and Mobilis to develop wide-ranging applications as well as increase awareness | · 2000 units were produced for deployment at customer end for evaluation · Exclusive license for manufacturing and marketing given to an industry, DSK-Worldman Computers Pvt Ltd, Pune. | --- | ---- |
| 39 | Process for Tamiflu – a Blockbuster drug to combat the menace of avian flu | --- | A 12 step process for production of tamiflu starting from (-) shikimic acid developed. | ---- |
| 40 | Development of production system for Tea Polyphenols and their condensed products | · Green process developed for extraction and purification of catechins—amino acids as by-product; · Process upscaled to 40kg leaves/batch · Technology transferred to Baijnath Pharmaceuticals Pvt Lt, Paprola, HP | · New genes for catechin biosynthetic pathway from tea plant found that were registered with NCBI; · Polyphenol oxidase (PPO) gene in catechin biosynthetic pathway cloned and expressed; · Qualitative screening of tea for clonal variation in PPO activity undertaken in 700 tea accessions. | · Publications: 9 · Patent Granted in USA & China |
| 41 | Development of an integrated micro PCR system with In-situ Identification & Validation of handheld diagnostic platform for HBV detection | Technology developed for · Micro PCR Device · Sample Preparation Device · Microchips for detection of Tuberculosis, Malaria, Dengue, Chikungunya, Hepatitis B and H1N1 Commercialized by M/s Bigtech Pvt ltd | ---- | 70 patents granted. |
| 42 | A prospective study to correlate gene signatures with clinical outcome of astrocytomas and identification of potential therapeutic target(s) | --- | · Identified glioblastoma biomarker genes; · Shortlisted genes from microarrays as potential diagnostic marker genes | --- |
| 43 | Development of high throughput marker assisted selection systems for improvement of drought tolerance and fibre quality related traits in cotton | --- | · More than 2000 SSR markers were identified in cotton which were developed in Gossypium hirsutum genotype for future R&D in improving cotton varieties; submitted in cotton marker database; · Recombinant inbred lines of one variety developed that showed best performance for yield and quality parameters. The line was included in multilocational trial program of TNAU, Coimbatore. | 3 Publications |
| 44 | Novel method for development of B-type Natriuretic peptide (BNP) for diagnosis and treatment of congestive heart failure | A prototype diagnostic device for detection of Congestive Heart Failure was successfully developed | · A novel expression system that can produce large quantities (10mg/L) of highly pure rhBNP for therapeutic or for diagnostic usage was developed; · The purified rhBNP was characterized for its purity and activity and safety in animal studies; · The knowhow for liposomal encapsulated formulations generated. | 2 Publications |
| 45 | Development of Next Generation Plasma Display Technology and a 50 inch High Definition (HD) TV prototype | A prototype of 50’’ HD PDP with existing materials / processes including its electronics was designed, developed and demonstrated. | ---- | Patents filed: 19; Publications: 18 |
| 46 | Wireless Sensor Network Chipset based on Ultra –Wideband Technology | · Prototype (4x4 MIMO UWB) developed · Working prototype for transferring data at the rate of 1 Gbps wireless link using a non-standard protocol (3 GHz band) demonstrated | --- | 3 patents filed |
| 47 | Conversion of cellulose and hemi-cellulose into sugars and ethanol | --- | · Microbial consortia for production of various enzymes; · Scale up process for enzyme production | ---- |
| 48 | Conversion of Bioglycerol into value added chemicals & Scale up of CSIR-NCL Process for selected hydrogenolysis of glycerol to 1, 2-Propan-di-ol | Technology for conversion of glycerol into 1, 2-PDO developed. | --- | A US patent has been granted. |
| 49 | Novel approaches for production of hybrid seeds with characteristics of improved insect resistance and higher yield | ----- | Rice component · Seeds & data (morphological & molecular) on 566 rice genotypes · Diverse parental lines for inter-varietal crosses – 200 identified as promising · 168 diverse restorer lines · 200 hybrids out of which 21 found promising – 5 as most promising · 380 promising iso-cytoplasmic F7 restorer lines from 25 most promising commercially cultivated hybrids Cotton component • Barnase male sterile lines • Barstar male sterile lines • cry1Ec construct with novel promoter & transgenic lines • cry2Ax1 construct & transgenic lines • AMTL lectin construct • CEA lectin construct • 1 Barbadense pure line • 4 hybrids • 4 combiners each from 4 heterotic groups | Patents: 3; Publications: 8 |
| 50 | Meso-scale modeling for Monsoon predictions - Phase II | Same as Sr. No. 8 | --- | --- |
| 51 | Design and development of cushion bonded organic ceramic clutch discs | Cushion Bonded/ Rigid Bonded Organic, Ceramatallic Cookie & Single/Dual Sintered Buttons (Copper / Iron Based), Ceramic Cookie & Annular Ring Clutch Discs and Matching Cover Assemblies’ have been developed | 5 Patent filed 14 Design Registered | |
| 52 | Intelligent video surveillance system | Intelligent video surveillance solutions comprising of flexible and reliable Digital Video Recorder (DVR), video decoder and the open network video interface forum (ONVIF) stack developed and commercialized. | --- | 4 Publications 3 US patents granted |
| 53 | Novel therapy for management of sepsis and Novel therapy for management of sepsis Phase II study | · The drug is already in market for other indication. · For management of sepsis—awaiting marketing approval for new indication for management of gram negative sepsis | · Phase IIa clinical trial for safety dose showed faster clinical, functional and microbiological recovery when combined with standard therapy; · Phase IIb/Phase III multicentre clinical trial completed and there was 10.89% absolute reduction and 55.56% relative reduction in mortality in Treatment Group compared to Control Group which is clinically relevant and statistically significant (p = 0.0229). · The survival data of died patient’s shows that there is significant difference between two arms for the days of death. Death was delayed in the treatment group compared to control group. [p-value: 0.0001, Hazard Ratio: 0.448 (95% CI: 0.311-0.646)]. · Product developed and named “sepsivac”and is commercialized by M/s Cadila Pharmaceuticals Ltd, Ahmedabad | One product patent |
| 54 | A syndromic approach to diagnosis of infections: development of DNA macro-chips for simultaneous detection of pathogens causing AES (Acute Encephalitic Syndrome) and septicaemia | The project was successful, culminating with the development of three diagnostic kits – two for simultaneous identification of all pathogens causing Acute Encephalitic Syndrome and septicaemia and the third one for identification of the antibiotic sensitivity of the bacteria causing septicaemia. | ---- | ---- |
| 55 | Evaluation of RNAi-based constructs for conferring resistance on transgenic rice against the blast fungus Magnaporthe grisea | --- | · Transgenic rice plants of T5 generation were developed that showed good level of resistance against blast fungus; · Technology platform for developing transgenic rice plants ready with gene overexpression and gene silencing targets for clast fungus in place. | ---- |
| 56 | Development and characterization of an indigenous vaccine for Johne’s disease | Two formulations of vaccine i.e. JD Oil and JD Gel and companion diagnostic for JD developed. | --- | Patent filed: 2 |
| 57 | Development of Caerulomycins as novel immunosuppressive agents to prevent organ rejection after transplantation and to address various auto-immune and allergic disorders | Analogues of original molecule, Caerulomycin, an immunosuppressive agent for organ rejection, were developed and tried for activity and IND studies; However the selected analogues did not show the activity of immunosuppression and the project was closed. | 1 Patent filed; 5 publications | |
| 58 | Novel DPP IV inhibitors for the treatment of Diabetes & Novel DPP IV inhibitor – Phase I/II Study: A safety, pharmacokinetic and pharmacodynamics study of CPL-2009-0031 in Healthy Volunteers and patients with Type 2 Diabetes mellitus (T2DM) | · One novel DPP IV inhibitor identified from among synthesized molecules; · Novel process developed for synthesis of the molecule; and · Drug development related pre-clinical studies on the selected molecule for IND completed. · In Phase-I study, the drug was found to be safe and well tolerated at all dose levels, without any major safety concerns in healthy volunteers. · Additionally, it demonstrated linear pharmacokinetic characteristics after oral administration. · Phase-II prospective, randomized, double blinded, parallel group, multicentric, comparative clinical study indicated efficacy of the compound. No deaths, other SAEs or other significant AEs were observed in any of the patients during the entire study · Based on the Phase-II data, the Monitoring Committee suggested comparative study of the drug with Sitagliptin in phase III clinical trial. The proposal has been approved by DCGI. | · Patent: 3 PCT (1 patent granted in 5 countries; 1 granted in 2 countries); 1 filed in India and Europe | |
| 59 | Biofuel from marine microalgae | · Novel process developed for harvesting of micro algal biomass. · Process developed for biodiesel production from a marine microalgal species at cost ~ Rs 125 per litre. Process patent granted. | · Publications: 64 · Patents: Filed-1; Granted-5 | |
| 60 | Development and production of a therapeutic monoclonal antibody against eNAMPT, a novel inflammatory target | · Ultra-large naïve human phage display libraries (2.79 x 1011 cfu total); compare with Xoma’s (2.5 x 1011 cfu total); · Fast ultra-large library making abilities – 30-45 days from start to sequence characterization; · Proof-of-concept of practical applicability of antigen-antibody equilibrium and kinetic principles for phage panning and isolating high affinity phage pools; · Fast panning – 21-30 days for 4 rounds of solution panning to monoclonal isolation; · Emphasis on studying monoclonals as Fab proteins in solution (not fusion with phages) and novel solutions for phenotyping to isolate “genotype true” hits; and · Establishment of novel solutions for kinetic ranking of Fab hits as proteins. | Antibody Phage Display Library’ filed on 23rd June, 2017 with the ID PCT/IN2017/050257 | |
| 61 | Biomarker Neck and Head Cancer | --- | · Robust data generated which include complete clinical analysis combined with transcriptome profiling of 350 head and neck cancer (HNCC) patients’ samples The probable markers can now be visualized that can be considered for making chip based diagnostic prototype; · A prediction algorithm has been developed which gives prediction of more than 95% accuracy. The 83 gene set showing strong prediction power of HNCC occurrence can now be superimposed for multivariate clinical analysis. Thus a proof of concept with patients’ samples has been established; · A signature of 34 transcripts correctly predicted 41 of 50 samples (82% Prediction accuracy) in the validation phase. Prediction analysis based on PNI status and tumor size showed prediction similar to the whole sample. The 34 transcript signatures are novel, specific for Indian population and do not overlap with 102 gene signature obtained in the Dutch study. | A PCT filed for the biomarkers. |
| 62 | Design, Development and demonstration of high performance parabolic trough based 300 kW Solar Thermal Power Plant | ---- | · A new Magnetron Sputtering Pilot Plant System which is capable of co-deposition and as well sequential deposition of six different types of coatings to address the need for various functionality of (a) IR reflection, (b) Diffusion barrier, (c) Multilayer cermets, (d) Multilayer antireflection coating etc.; · Tracking System with features: (i) Hydraulic System coupled with Advance Controller (ii) Inclinometer for absolute measurement of position (iii) Drives 6 modules of three Troughs on each side (iv) Accuracy 1.7 mrad (v) Validation at DLR, Germany is underway; · Photo-receiver Tube (Heat Collection Element) for 4 m size with measurement of: (i) Thermal loss (ii) Assess performance in outfield natural Solar Radiation (iii) Vacuum leak test (iv) Vacuum integrity with time and (v) Optical efficiency test on trough; validation to be done at DLR, Germany; · Highly engineered Concentrating Parabolic Trough Collector assembly with unique features was designed, developed and demonstrated; and · A high precision Glass to Metal Seal with High Temperature stability for Heat Collection Element developed and integrated into the HCE as per the satisfaction of industry. | ---- |
| 63 | Development and demonstration of 500 W SOFC Stack with hydrogen as fuel and testing of short stack with synthetic gas & Development and demonstration of 1 kWe SOFC Stack with hydrogen & Air and 500 We SOFC Stack with reformed natural Gas and Air | Not yet commercialized. | Developed and demonstrated 3 different prototypes of capacities 200W, 500W and 1.0 kW of Solid Oxide Fuel Cell Stack using hydrogen and Air+O2 with peak power density of 0.31 W/cm2 at 800oC. The other achievements have been the development of thermally cyclable new glass sealants for SOFC stack and theoretical modeling of the cell design. | Patents: 3 & Publications: 15 |
| 64 | The next generation wind power technology: contra-Rotor Wind Turbine (CRWT) System | Projects foreclosed | --- | --- |
| 65 | Development and commercialistion of “Vennfer” – unique H.264 high definition software based multiparty, multipoint video conferencing solution on multipoint network transmission protocol | High definition software based video conferencing solution – ‘Vennfer HD’ using H.264 video codec multiparty, multipoint video conferencing applications on multicast network transmission protocol has been developed. | --- | --- |
| 66 | Development and commercialization of NXR-4D: A lithium-Ion battery powered 4-door next generation electric Car (4-Seater Capacity) - Mahindera Reva Electric Vehicles Pvt. Ltd., Bangalure | First four-door electric vehicle to be entirely indigenously designed, developed and commercially produced in India and meeting global automotive quality standards | --- | --- |
| 67 | Design and fabrication of All-Fibre Supercontinuum Light Source with application demonstration to detect fake pills: Vinvish Technologies Pvt. Ltd., Thiruv’puram | Developed and Demonstrated two products viz.: (i) Supercontinuum Light Generation Source; and (ii) Broadband Confocal Microscope. The developed PCF technology had been transferred to the industrial partner by CSIR-CGCRI through a Technology Transfer Agreement. | --- | ---- |
| 68 | Development and commercialization of Soleckshaw Lite – An Innovative Electrical Green Transport Platform: Kinetic Engineering Ltd., Pune | · Indigenous Electrical three wheeler. · Central Motor Vehicle Rules (CMVR) certification for the same has been obtained | --- | --- |
| 69 | Customized adaptation of nonClonableID technology to establish authenticity of medical products: Bilcare Ltd., Pune | The nonClonableID technology was demonstrated for its utility in: (i) establishing the product accountability in the area of medical products; (ii) secured traceability from the point of origin to the point of dispensation, authenticity check and establishing e-pedigree; and (iii) improving medication compliance by patients | ---- | ----- |
| 70 | Development of a diagnostic system for affordable, point of need testing to manage HIV and TB: Reametrix India Pvt. Ltd., Bangaluru | · ReaSLR CSM Kit Ver 1.0 (ReaFilter based filtration and Concentration of cells by centrifugation) - is available for evaluation and sale; | · ReaSTAT CD4 assay on IMMEDIA - External validation of ReaSTAT CD 4 assay kit is ongoing; · ReaSLR CSM Kit ver 2.0 (magnetic beads and staining) - External validation is being carried out at three centers; and · ReaTBDx – Antibody licensed from Albert Einstein School of Medicine, New York; Optimization of is being carried out at SGPGIMS Lucknow; External validation of ReaTBDx will be carried out at external site. | --- |
| 71 | Development of non-hazardous process for the synthesis of Di Methyl Carbonate (DMC) from methanol and urea | Developed two-step process for the synthesis of dimethyl carbonate (DMC) from methanol and urea | · Developed Two Step Process for the synthesis of DMC from methanol and urea. · Novel reactor configuration proposed for both the steps. · Protocol standardized for regeneration of the used catalyst · Demonstrated Process at Bench Scale Set-up (45 gm/hr); · Demonstrated the process for synthesis of other higher dialkyl carbonates from corresponding alcohols · Filed six Patents covering Catalysts, Process and catalyst regeneration strategies | Publications: 1; Indian Patent granted : 1 |
| 72 | System based computational model of skin (SCoMOS): CSIR-IGIB, Delhi | Computational software named “eskin” encompassing varied features as mentioned in next column launched by industry for services. | · A unique repository of 2600+ skin specific genes and their associated skin pathways obtained by manual curation of biomedical literature (called Skin base). · Detailed molecular interaction maps of 35 skin physiology associated biological pathways (e.g. cornification, keratinocyte differentiation); · Offers skin centric analysis of gene expression data with overlay functionality for easy identification of pathways most relevant to a phenotype; · Offers Functionality for comparing unknown compound’s gene expression signature with those related to skin-specific phenotypic endpoints (e.g. hypopigmentation, desquamation)—Skin predict · Facility for extensive reporting module to generate generic as well as customized reports for the analyses performed; and · User-friendly interface and optimized architecture for computation-intensive jobs; · Gene Signatures expressed by human skin in response to ten compounds of five different groups i.e. hyperpigmenting, hypopigmenting; hydrating; photo-oxidative and desquamation that are commonly used by cosmetic and pharma industries in their products, were generated and incorporated in the software. | Copyright for software |
| 73 | Integrated technological solutions for security and operations based on UV sensor technologies | Few developed material products have been commercialized by M/s Security Printing and Minting Corporation of India Limited (Wholly owned by Govt. of India). | · Developed Invisible UV sensitive inks fluorescing in blue color as per the industry standards; and · Six different Pi-MAD (Programmable Invisible Marker Authentication device) prototypes with varying functionality have been developed leveraging open source Arduino platform which can clearly distinguish various fluorescent colors. | --- |
| 74 | Design and development of photonic crystal cladded and double called Er and Er/Yb fibers, and application demonstration of high-power optical amplifier | A prototype of high power amplifier (EDFA) was designed, developed and demonstrated. | --- | --- |
| 75 | Demonstration and validation of a 5 kW HT-PEMFC based combined cooling and power system | Not yet commercialized. | · 6.0 kW Fuel Cell Test Station from Lean Cat has been installed and commissioned; · 3.0 kW Fuel Cell Stack with 100 Cells has been built; · Considerable progress has been made on the aspects of Reformer, Power Conditioner, BoP components, System Integration and Packaging of the system; and · Design of Vapor Absorption cooling system initiated. | Patent Filed: 1 Publications: 10 |
| 76 | Demonstration and Validation of a LT-PEMFC system for automotive application | Demonstration of hydrogen fuel cell prototype in running the sedan car. | · A 30-Cells stack has been built using the MEA that were created by hot pressing the electrodes fabricated. | Publications: 1 |
| 77 | Development of an antidiabetic agent based on the phytopharmaceutical drug guidelines from Enicostemma littorale blume | --- | Four markers have been identified for development of phytopharmaceutical formulation | --- |
| 78 | Kappaphycus alvarezii and red seaweed based formulations for improving productivity and health of dairy and poultry animals | · Two formulations developed and validated ü One formulation for improving health including immunity enhancement and productivity of broiler chicken ü Another formulation for improving health and immunity of crossbred calves and dairy cattle as also having anti-methanogenic property. | --- | Publications : 2 |
| 79 | Automation of Ghani operation through vacuum conveying system | Fully automatic Ghani plant has been designed, fabricated, installed and commissioned at M/s Khandelia Oil Mills, Alwar. | Complete package for conversion/retrofitting of traditional ghani plant into fully automatic ghani plant. | Patent Filed : 1 |
